NBN and hereditary disease: Finally, Chiang et al. pointed out that Nijmegen syndrome, a rare genetic disorder of chromosomal instability associated with cancer predisposition, radiosensitivity, and chromosomal instability, involves the NBS1 (p95 or nibrin) gene, part of the MRE11/RAD50/NBS1 complex which is an essential component of the NHEJ repair system [89].