c-MYC plays a role in several types of B-cell acute leukemia: B lymphoblastic leukemia (B-ALL) with t(9; 22) and BCR::ABL1 rearrangement, B-ALL with t(v; 11) KMT2A rearrangement, B-ALL with the t(12; 21) and ETV6::RUNX1 rearrangement and B-ALL with other chromosomal rearrangements as TCF3::PBX1 in leukemia derived from pre-B lymphocytes [24]. This evidence concerns the gene TCF3 and acute lymphoblastic leukemia.