Gene editing studies have shown that NPM1 mutant leukemias are dependent on menin and MEIS1 for their leukemogenic function, and knocking out these genes disrupts the menin-HOX-MEIS1 axis that leads to differentiation, loss of proliferation, and impaired leukemogenesis [54,55,56,57,58]. Here, MEN1 is linked to leukemia.