Finally, the enrichment of proteins related to response to oxidative stress (PARK7, APOE, GCLC, GPX2, PRDX3, ROS1), cell redox homeostasis (GCLC, PRDX3, PRDX6), and oxidative phosphorylation (ATP5F1D, ATP5MG, ATP6V1G1, NDUFS3, COX6B1) (Supplementary File S5) in the metachromatic group aligns with some of the mechanisms known to underpin mast cell degranulation in asthma-associated pathology in humans; namely, the overproduction of ROS with subsequent redox imbalance and oxidative stress [48,53]. Here, APOE is linked to asthma.