A similar effect is found in multicellular aggregates formed by cultured HSC-2 squamous carcinoma cells, where EGFR is recruited to sites of E-cadherin-mediated adhesion between cells, forms a complex with E-cadherins, is activated in a ligand-independent manner, and induces ERK1/2 phosphorylation. Here, CDH1 is linked to squamous cell carcinoma.