In HT1080 and U87MG cancer cells, the CD44s isoform of CD44 predominantly expressed in these cells interacts with Rab7A in the late-endosome/lysosome compartments, reduces levels of the GTP-bound form of Rab7A, and inhibits the Rab7A-mediated EGFR degradation. The gene discussed is RAB7A; the disease is cancer.