HPSE and neoplasm: Heparanases are a family of endoglycosidase enzymes that degrade the glycosaminoglycan heparan sulfate (HS) in the ECM, resulting in loss of basal membrane integrity and release of heparan-sulfate-associated angiogenic and growth-promoting factors that subsequently stimulate tumor blood vessel growth, cell invasion, migration, adhesion, metastasis, differentiation, and proliferation [78,79,80].