Reduction in F-actin stress fibers by 54% to 28% compared to control; reduction in melanoma adhesion to fibronectin by 35% to 64%; reduction in phosphorylation of FAK by 50% to 65% and paxillin by 55% to 70% at various concentrations; reduction in focal adhesions per cell by 36%. The gene discussed is PTK2; the disease is melanoma.