HPSE and melanoma: Other approaches to suppress heparanase expression in melanoma stroma through genetic constructs, including adenoviral vectors carrying an antisense sequence of the heparanase gene HSPE-1, have also spread and have shown efficacy in B16-B15b/70W melanoma lines and mouse models [103], artificial microRNA (miRNA) on A375 cell model [104], or small interfering RNA (siRNA) in B16-BL6 mouse melanoma in vivo [105].