Interestingly, although the CD4+ T cells from AD patients do not show significant changes in global methylation patterns compared to healthy controls [99], CD4+ T cells expressing the cutaneous lymphocyte antigen (CLA) (CD4+CLA+ T cells) showed significant differences in DNA methylation in 40 genes, including IL-13 gene, compared with healthy controls [100]. The gene discussed is SELPLG; the disease is Alzheimer disease.