IGHE and Alzheimer disease: For example, in a 2,4-dinitrofluorobenzene (DNFB)—a murine model of AD-like skin lesion, intraperitoneal injection of RvE1 significantly decreased ear swelling and improved skin lesions, accompanied by decreased serum IgE levels and production of IFNγ and IL-4 by activated T cells, and reduced infiltration of eosinophils, mast cells and T cells in the skin lesions [37].