S100A8 and Alzheimer disease: Genetic transcriptome analysis revealed that 74% of genes whose regulation was disrupted in acute AD were also observed in chronic AD, including genes involved in epithelial differentiation (IL-20, KRT16, KRT6B, S100A8, and S100A9), antimicrobial and immunomodulatory chemokines (CXCL1, CXCL6), T cell regulation (TNIP3, CLEC3A) and Th2 cell differentiation (IL-19).