Among these cytokines, MCP-1 demonstrated superior predictive value for severe CRS, with a sensitivity of 100% and specificity of 95%, across different grades of CRS in an anti-CD19 CAR-T study (levels of IFNγ, IL-6, IL-8, IL-10, IL-15, MCP-1, TNF receptor p55 (TNFRp55), and MIP-1β have been evaluated) [12]. The gene discussed is IFNG; the disease is congenital rubella syndrome.