CNR1 and Anxiety: The authors also found that CAE increased CB2R density in PFC microglia, and CB2R activation by its selective agonist AM1241 that does not bind CB1R prevented CAE-induced anxiety-like behaviours, mitigated microglial activation by reducing their pro-inflammatory M1-like phenotype, restored normal microglial morphology and reduced the secretion of inflammatory cytokines [219].