Another study demonstrated that CD11b-positive MGEVs could be obtained from the parietal cortex of cryopreserved human brain tissue of late-stage AD and a comparison with age-matched control cases analyzed using integrated multiomics identified an increase in disease-associated markers like FTH1, TREM2, upregulated levels of tau and synaptic proteins, and elevated cholesterol and reduced DHA-containing lipids as well as specific miRNAs (miR-28-5p, miR-381-3p, miR-651-5p, and miR-188-5p) that are linked to immune and cellular senescence [70]. Here, MAPT is linked to Alzheimer disease.