STIM1 and Thrombocytopenia: In TAM/STRMK patients and murine STIM1 models, thrombocytopenia is concomitant with prolonged bleeding times [7,10,11,15,16,17,20,21,23,28,29,30,31,32,33,35,36], and accordingly, Orai1V109M/+ mice displayed a reduction in circulating platelets (Figure 3E).