In addition, analyses from TIMER suggested that the expression level of ACTA2, as well as FGF7, is positively correlated with the M2 macrophage population (Figure 5B,C), which was confirmed by IHC staining of CD163, ACTA2, and FGF7 in our established ccRCC tissue micro-array (Figure 5D,E). Here, CD163 is linked to nonpapillary renal cell carcinoma.