EGFR and nasopharyngeal carcinoma: As shown in Figure 6B, the oncogenic signaling molecules p-EGFR, p-Axl, p-MEK, and p-ERK were downregulated after treatment with either Z239-1907, ZAXL239, or ZEGFR1907 in C666-1 and NPC/HK-1 cells, as well as the downregulation of c-Fos and c-Myc genes transcription.