Considering the active candidate in blueberry and the underlying molecular mechanisms, using a FAA-induced steatosis in vitro (L02 cells) model, Xu et al. demonstrated that the anthocyanin malvidin-3-O-glucoside is the active constituent that ameliorates NAFLD by modulating the transcription factor EB (TFEB, a principal regulator of lysosome genesis)-mediated lysosomal function and activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant responsive element (ARE) signaling pathway, mitigating the redox state [72] (Table 1) (Figure 4). Here, NFE2L2 is linked to metabolic dysfunction-associated steatotic liver disease.