In cardiac failure and IR injury, higher pro-inflammatory cytokines levels induce cross-talk with ROS production [166], particularly the interleukins, transforming growth factor-β, nuclear factor κB, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-α, which determine ROS and RNS amplification and cross-talk production methods [167]. The gene discussed is CCL2; the disease is heart failure.