In 2010, Duewell et al., showed that animals that were genetically modified to be prone to developing atherosclerosis and who were receiving bone marrow transplants from NLRP3-deficient, ASC-deficient, or IL-1αβ/b-deficient donors were resistant to developing atheroma plaques in response to a HFD [85]. This evidence concerns the gene NLRP3 and atherosclerosis.