Normally, a transcription factor in adipogenesis, CCAAT/Enhancer-Binding Protein α (C/EBPα), can be upregulated by the MDI induction for the development of obesity [63]; moreover, this transcription factor can be downregulated by the nuclear translocation of β-catenin [64]. This evidence concerns the gene CEBPA and obesity due to melanocortin 4 receptor deficiency.