Another recent study revealed that chronic hypoxia capable of activating HIF-1 is detected in AD brains and retinas, especially in microvascular endothelial cells, which leads consequently to the formation of NLRP1 inflammasome and upregulates the signaling cascades of “adaptor molecule apoptosis-associated speck-like protein containing a CARD (ASC)-caspase-1- IL-1β”. This evidence concerns the gene HIF1A and Alzheimer disease.