The downregulation of HIF-1α, which regulates the two major brain glucose transporters GLUT1 and GLUT3 for glucose uptake into neurons, was observed in AD brains; this decrease in HIF-1/GLUT1/3 correlated to the hyperphosphorylated tau and higher density of NFTs [110]. The gene discussed is SLC2A1; the disease is Alzheimer disease.