Consistently, an iron chelator M30 capable of upregulating HIF-1α with heightened expression of its downstream target genes, including enolase-1, EPO, p21, tyrosine hydroxylase, VEGF, and insulin signaling pathway, in cortical neurons and APP/PS1 AD mice, may have anti-Alzheimer characters [153,154] (Table 1). Here, HIF1A is linked to Alzheimer disease.