HIF1A and Alzheimer disease: Triple (3×-Tg AD; PS1M146V, APPswe, tauP301L) transgenic AD mouse brains also showed hypoxic vessels expressing HIF-1α, which resulted in the formation of NLR family pyrin domain-containing 1 (NLRP1) inflammasome to further stimulate HIF-1α expression and ultimately formed an HIF-1α-NLRP1 vicious circuit [113].