NR4A2 and experimental autoimmune encephalomyelitis: Lastly, the Nr4a2 gene-encoding product, nuclear receptor subfamily 4, group A, member 2 (NURR1), is upregulated in MS patients in the pre-disease state [113] and prevents autoimmune neuroinflammation in the experimental autoimmune encephalomyelitis (EAE) model of MS [114].