ADI1 and Alzheimer disease: While individual worm models of AD are described in detail below and in Figure 1, it is worth mentioning here a study by Apostolakou et al. that utilized protein–protein interaction (PPI) networks to model amyloid precursor protein (APP) and tau in humans and their orthologs APL-1 (APP-related protein 1) and PTL-1 (protein with tau-like repeats-1) in worms [28].