Conversely, the expression levels of GSR, a primarily cytosolic enzyme that regenerates GSH from GSSG using NADPH, along with the combined expression levels of NADPH-generating enzymes (IDH1, IDH2, PGD, and G6PD), were upregulated 1.3 to 2.4-fold in these PCa cell lines (Table S3). Here, IDH2 is linked to posterior cortical atrophy.