Along with the previously discussed changes in peroxisomal antioxidant enzymes, we observed a notable increase in the levels of GSR, maleylacetoacetate isomerase (GSTZ1), and PRDX2, and a decrease in glutathione peroxidase 4 (GPX4), mitochondrial glutathione S-transferase 3 (MGST3), glutathione S-transferase omega1 (GSTO1), TXN, glutathione peroxidase 1 (GPX1), microsomal glutathione S-transferase 1 (MGST1), and GSTP1 in PCa cells compared to the normal prostate cell line. This evidence concerns the gene GPX4 and posterior cortical atrophy.