SOD2 and posterior cortical atrophy: Regarding H2O2 degradation, our data highlight several key points: (i) the protein expression levels and activity of CAT are upregulated in the AR-positive 22Rv1 and LNCaP PCa cell lines (Figure 6), (ii) SOD2, an H2O2-producing enzyme primarily located in the mitochondrial matrix, is downregulated in LNCaP and PC3 cells, and (iii) MARC2, another H2O2-degrading enzyme found in mitochondria and peroxisomes, is upregulated in LNCaP and PC3 cells (Figure 5).