SETX and amyotrophic lateral sclerosis type 4: Mutations in the SETX gene have been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia type 2 (AOA2), underscoring the importance of senataxin in both neuronal health and genomic integrity [45,46,47].