TARDBP and amyotrophic lateral sclerosis: Additionally, PCBP-2 has been shown to fit into a sequence-specific alpha-globin mRNP complex, which can become part of TDP-43-positive cytoplasmic inclusions, destabilizing mitochondrial and ribosomal alpha-globin mRNA in neurons, and further disrupting the function of the mitochondrial electron transport chain (ETC) in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) [38].