IL5 and Increased total eosinophil count: Interleukins, particularly IL-4 and IL-5, are responsible for the synthesis of IgE, stimulating eosinophilia, modulating eosinophil function, and enhancing the proliferation of mucosal-type mast cells [67]; however, the inhalation of H2 has been shown to reduce IgE levels and inhibit inflammatory responses.