FOXO3 and melanoma: miR-182 induces increased invasion and metastasis by binding to the tumour suppressor F-box/WD repeat-containing protein (FBXW), and its binding to FOXO3 and MITF appears to be associated with melanoma progression, and miR-182 is a target of epigenetic modulation with hypermethylated CpG islands in melanoma cells [14].