In 2015, Zhou et al. overexpressed miRNA-33a in the A375 cell line (amelanotic and metastatic) and in parallel inhibited the expression of this miRNA in the non-metastatic WM35 and metastatic WM45 cell lines; in this study, the authors demonstrated that miRNA-33a can inhibit the proliferation, invasion, and metastasis of human melanoma cells via the inhibition of HIF-1α. The gene discussed is HIF1A; the disease is melanoma.