In addition, elevated levels of CTBP1 in melanoma have been associated with increased proliferation and DNA damage [110]; although by sequencing CTBP1 mRNA was not found to be differentially expressed in the two conditions evaluated, it is possible that by qPCR, differences related to the decrease in DYRK1B could be found (Figure 3). The gene discussed is DYRK1B; the disease is melanoma.