A study in A375 cells and G361 cells showed that non-thermal plasma (NTP)-induced cell damage and caspase activity in G361 cells decreased in the presence of cytoglobin through the activation of the NRF2 pathway, suggesting that cytoglobin expression and the presence of melanin increased the resistance of melanotic melanoma cells to oxidative stress damage by the activation of antioxidant systems [85]. Here, CYGB is linked to melanoma.