MITF and melanoma: However, other mechanisms are known by which NRF2 contributes to melanogenesis, as it inhibits MITF, developing dedifferentiated and invasive melanoma [84], and exerts a function on the redox capacity of melanoma, being more expressed in advanced, metastatic, and drug-resistant melanoma by nuclear accumulation without affecting the Kelch-like ECH-associated protein 1 (KEAP1) levels in the cytoplasm, performing a positive regulation of NRF2 target genes [85].