The T allele of rs13053109 in the promoter region of CRYAA is associated with increased risk of age-related cataracts and shows increased binding by KLF10 with consequent decrease in CRYAA transcription [84], providing indirect support for the role of the NFE2L2 pathway in age-related cataractogenesis. This evidence concerns the gene NFE2L2 and Age-related cataract.