SESN2 and breast cancer: Previous studies show that BA induces the expression of stress-induced gene SESN2 in breast cancer cell lines and that treatment with BA and derivative CAI3 leads to an increased expression of genes involved in zinc homeostasis in breast cancer cells, including an overexpression of metallothionein 1 (MT1), zinc transporter 1 (SLC30A1), and S100 calcium and zinc binding protein (S100P) [12].