Among the genetic models, hepatocyte-specific PTEN KO mice develop features such as steatohepatitis, liver fibrosis, and subsequent carcinogenesis, closely mimicking the progression of human MASH, but with unique variations in pathogenesis, such as increased insulin sensitivity without the typical obesity-associated pathophysiology [16,17]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.