A case-control study found that CAD patients confirmed by angiography (n = 105) had significantly increased plasma 8-isoprostane F2 (8-iso-PGF2α, produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids) and reduced paraoxonase and arylesterase activities of PON1 compared to healthy controls (n = 45) [58]. Here, PON1 is linked to coronary artery disorder.