Bioinformatic analysis of pathway enrichment in the high and low PON1 mRNA expression groups showed that the PON1 gene inhibits key signaling pathways, such as the PI3K/Akt/mTOR signaling, the cell cycle G2 checkpoint, the TGF-β signaling, and the Wnt/β-catenin signaling, which play a crucial role in pathogenesis and progression of HCC [34]. This evidence concerns the gene PON1 and hepatocellular carcinoma.