Participants carrying PON1-192QQ alleles had a significantly increased risk of adverse CVD outcomes such as death, myocardial infarction (MI), and stroke, compared with PON1-192RR and PON1-192QR carriers over a 3-year-followup (18.0% vs. 13.6%, adjusted hazard ratio 1.48, p = 0.01) and all-cause mortality (11.1% vs. 6.75%, adjusted hazard ratio 2.05, p = 0.001). This evidence concerns the gene PON1 and Stroke.