ATF4 and familial pancreatic carcinoma: The treatment with CBD led to an increase in ATF4 levels followed by apoptosis in HCT116 and DLD-1 colorectal cancer cells [174]; the upregulation of ER stress biomarkers, such as ATF4 and GRP78, was also reported in pancreatic cancer cell models after treatment with the phytocannabinoid [175].