CNR1 and diabetic kidney disease: A recent report described how high glucose levels upregulate the expression of the CB1 receptor, with detrimental consequences for the renal system; indeed, ER-stress-induced apoptosis in rat mesangial cells, via CB1 activation, exacerbates diabetic nephropathy, while the administration of a CB1 antagonist fully reverts this effect, impairing the antiproliferative and apoptotic processes [160].