Moreover, Gardner et al. demonstrated that the prognostic value of the index was independent from the value of the n-terminal pro B-type natriuretic peptide (NT-proBNP); when compared with patients with low NT-proBNP (<1000 pg/mL) and a negative HeartLogicTM index, patients ‘in alert’ had a 24-fold and a 50-fold increased risk of HF events at follow-up if NT-proBNP levels were low (<1000 pg/mL) or increased (>1000 pg/mL), respectively [6]. The gene discussed is NPPB; the disease is hydrops fetalis.