For proteins that were dysregulated only in moderate and/or under medication patients compared to healthy subjects, the Wiki-pathways found were the “network map of SARS-CoV-2 signaling pathways”, which include the upregulated proteins SERPINA10, LRG1, PF4, CPN1, APOC1, and the “RAS and bradykinin pathways in COVID-19”, which include the three upregulated proteins AGT, CPN1, PRKG1, and the “statin inhibition of cholesterol production” which also includes the upregulated proteins APOE, LCAT, and APOC1 (Figure 6). This evidence concerns the gene APOE and COVID-19.