VWF and von Willebrand disease (hereditary or acquired): Insufficiency in procoagulant factors (e.g., deficiency of clotting factors [except FXII], VWF or platelets, or their reduced activity) can lead to bleeding (e.g., hemophilia, von Willebrand disease [VWD]) [10,11], whereas insufficiency in anticoagulant factors (e.g., deficiency of PC, PS, or AT), or an excess of procoagulant factors can lead to thrombosis [6].