Thus, we can conclude that there might be an association between HF with or without concomitant renal impairment and NT-proBNP levels, but we could not demonstrate that this test, NT-proBNP level, can be used as a diagnostic test to predict HF (AUROC values closer to 0.5 than 1, the expected value) and no cut-off point could be established for the NT-proBNP level. This evidence concerns the gene NPPB and hydrops fetalis.