It is important to emphasize that substantially elevated levels of NT-proBNP, potentially due to the presence of subclinical cardiovascular disease, can no longer influence blood lipids and therefore neither BMI nor IR, which means that there is a state of low response to the natriuretic peptide and therefore loss of its inverse association under physiological conditions, in which the peptide has a greater preponderance to the remodeling of the heart [32]. This evidence concerns the gene NPPB and cardiovascular disorder.