FGFR3 and neoplasm: Luminal tumours exhibited an expression pattern similar to the intermediate/superficial layers of the urothelium, frequently activating PPAR target genes and showing a higher incidence of mutations in FGFR3, ELF3, CDKN1A, and TSC1, as well as overexpression of proteins such as E-Cad, HER2/3.