The optimal cut-off value for the optimized FIB-4 in T2DM, termed the Diabetes Fibrosis Index (calculated as 1.4013 × Age − 2.9859 × Plt × (1 − 0.00159 × Plt) + 5.8155 × AST × (1 − 0.00365 × AST) − 1.2014 × ALT + 56.7468 × BMI × (1 − 0.01467 × BMI)), was 715, yielding a sensitivity of 0.85 and a specificity of 0.52. The gene discussed is GPT; the disease is diabetes mellitus.