Finally, based on the associations found in the present study of the tendon regeneration failure phenotype with tendinopathy risk and higher episodes of disease manifestation, a hypothesis was created to describe the molecular mechanism by which TNC-rs2104772-A/MMP3-rs591058-T combination leads to the failure of tendon regeneration after mechanical load during the sports careers of high-performance athletes (Figure 4). The gene discussed is MMP3; the disease is disease of the tendon.