In addition, 1 × 109 CFU/mL B. longum BLG1 and 1 × 109 CFU/mL B. psychraelophilum Q5 together reduce the production of pro-inflammatory cytokines (approximately 6.5 times for TNF-α, 5 times for IL-6 and IL-10, p < 0.05 compared to DHT), suggesting that intestinal probiotic treatment can modulate BPH damage. This evidence concerns the gene TNF and benign prostatic hyperplasia.