The binding affinity of these three NB (named NB‐AGT‐1, ‐2 and ‐6) vary in three orders of magnitude, Kd ranging from 3.8 (NB‐AGT‐1) to ~ 5 × 10−3 (NB‐AGT‐6) nm to AGT‐LM (the minor allele of alanine:glyoxylate aminotransferase associated with the rare disease name primary hyperoxaluria type I, OMIM # 259900) [25] (Fig. S1). The gene discussed is AGT; the disease is primary hyperoxaluria.