In contrast with our findings, the study aimed to evaluate the effects of saffron aqueous extract (200 mg/kg body weight) on TNF-α levels in diabetic rats' liver, kidney showed that saffron aqueous extract normalized TNF-α levels in the liver and kidney tissues of diabetic rats, indicating its protective anti-inflammatory effect against hyperglycemia-induced inflammation [43]. This evidence concerns the gene TNF and Hyperglycemia.