Also, a study that investigated saffron's effects on liver inflammation and fibrosis using a CCl4-induced hepatic fibrosis mouse model showed 10 mg/kg and 20 mg/kg of saffron by inhibiting JAK/STAT3 phosphorylation in fibrotic livers, improved liver function, reduced inflammation, and decreased fibrosis [48]. The gene discussed is STAT3; the disease is Hepatic fibrosis.