Lysosomes hold potential as an attractive target for therapeutic intervention in ALS, as in addition to VCP, several other ALS associated genes have a role in lysosomal homeostasis (C9orf72, TARDBP, TMEM106B, TBK1, OPTN, SQSTM1) and several lysosomal storage diseases manifest neurological features [62, 64]. Here, TMEM106B is linked to amyotrophic lateral sclerosis.