VCP and amyotrophic lateral sclerosis: To examine whether changes in VCP mutant microglia are present in postmortem ALS spinal cord tissue we compared our hiPSC-derived VCP mutant microglia with the NYGC ALS Consortium database[22] consisting of 214 ALS patients and 57 healthy controls, which spans non-mutant cases (n = 161), C9orf72 (n = 36), SOD1 (n = 5), FUS (n = 2), and 8 other ALS mutations[51].