Mutations in over 30 genes are causative of ALS, including C9orf72, SOD1, FUS, TARDBP, and VCP (valosin-containing protein, p97) [1, 2]. ALS exists on a clinical, genetic and pathological spectrum with frontotemporal dementia (FTD). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.