The higher frequency (i.e., above the median frequency cutoff values) of each of the ten genes—UTRN, DGKH, IL17RA, ITGA6, CUL1, DDX50, MTFR1, EXOC7, NUP188, and KDM5B—was significantly associated with primary lung cancer, while odds ratios (OR) of MUC2 and ELAVL2 were significantly less than 1 for the BrM cohort. This evidence concerns the gene KDM5B and lung cancer.