ESR1 and breast carcinoma: We next evaluated the effect of these 39 molecules on cell viability in three breast cancer models: two ER-positive cells T47D (Fig. 2A) and MCF7 (Fig. 2B) to show the specificity of the compounds to ER, independent of the cellular background, and one ER-negative cell line MDA-MB-231 (Fig. 2C).