Comparing NHL with HL, ANA, and SSB were significantly elevated in HL (HL vs. NHL, ANA: 12.26 units vs. 8.29 units, P = 0.0480; SSB: 3.50 units vs. 2.39 units, P = 0.0234), whereas SSA levels, though higher in HL, did not reach statistical significance (HL vs, NHL, 2.38 units vs. 2.16 units, P = 0.4798) (Figure S5) (Table S3). The gene discussed is TRIM21; the disease is non-Hodgkin lymphoma.