Aggressive NHL displayed higher levels of autoantibodies compared to indolent NHL (aggressive vs. indolent NHL: ANA, 8.37 units vs. 7.21 units, P = 0.0262; SSA, 2.31 units vs. 1.64 units, P = 0.0136; SSB, 2.46 units vs. 2.07 units, P = 0.0280) (Fig. 2F-H) (Table S3). This evidence concerns the gene SSB and non-Hodgkin lymphoma.