Interestingly, prenatal to early postnatal treatment with P021 rescued developmental delay in pups and hippocampus dependent memory impairments in adult life in a mouse model of Down syndrome (DS), the Ts65Dn mouse [42], suggesting that providing CNTF neurotrophic support in a critical period of brain development can be an effective therapeutic strategy for developmental disability in DS. Here, CNTF is linked to Down syndrome.