The results indicate that in the Ang II-induced hypertension group, the expression levels of TNF, NFKB1, MAPK3, PTGS2, and RELA were markedly elevated compared to the control group, while the expression levels of HSP90AA1, HSP90AB1, PPARG, SIRT1, MAPK1, and PRKCA were significantly decreased. This evidence concerns the gene SIRT1 and Hypertension.