SHBG and Alzheimer disease: In the correlation analysis of neurocognitive abilities and indicators in patients with AD, significant positive correlations were found between SHBG and ADAS-Cog (r = 0.543, P < 0.001) (Fig. 1A), and significant negative correlations were found between SHBG and MMSE (r = -0.470, P < 0.001) (Fig. 1B), indicating an association between SHBG levels and cognitive abilities.