It was also associated with the accumulation of somatic copy number alterations (Discovery: P = 8.4 × 10−04, Validation: P = 0.040; Dataset EV2) and the presence of somatic cancer driver mutations in chromatin remodelling genes PBRM1 and SETD2 (P < 0.001; Figs. 2C and EV3C; Dataset EV2). Here, PBRM1 is linked to cancer.