Given that IL20RB overexpression activates pro-inflammatory macrophages in lung tissue (Zhu et al, 2024), and that LF2 was associated with macrophage signatures here, we hypothesize that IL20RB overexpression may similarly drive macrophage activation in ccRCC tumours and, in conjunction with EMT processes, contribute to the aggressive tumour characteristics observed. The gene discussed is IL20RB; the disease is neoplasm.