FN1 and nonpapillary renal cell carcinoma: This ccRCC component was associated with the presence of TME signatures related to EMT process, cycling endothelial cells, cell cycle kidney meta programmes, and myeloid cells (particularly fibronectin-positive tumour-associated macrophages/FN1_TAM) (all P < 0.001; Figs. 2B and EV3B).