PNPLA3 and acute lymphoblastic leukemia: The rs738409 (PNPLA3) variant was studied in relation to its association with liver damage in a multi-ethnic cohort of pediatric ALL patients undergoing therapy, where it was found to be associated with altered liver function, as evidenced by increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels21.