FTO is primarily involved in energy homeostasis, demethylating m6A in various RNA species, including cellular mRNA, which impacts multiple biological processes.676 ALKBH5 not only demethylates m6A-marked mRNA but also m6A-marked single-stranded DNA (ssDNA), influencing oncogenic or tumor-suppressive activities.677 Over the years, numerous small molecules targeting these m6A writers have been identified and designed, showing promising therapeutic efficacy in vitro and in vivo and advancing the development of epigenetic drugs. The gene discussed is FTO; the disease is neoplasm.