CD274 and cancer: This domain forms a hydrophobic pocket essential for recognizing m6A modifications.725 Elevated levels of YTHDF proteins have been associated with the progression of various cancers.726 Conversely, reducing these proteins can synergistically enhance the effectiveness of ionizing radiation and anti-PD-L1 therapies in reducing cancer burdens.727,728 This underscores the potential of YTHDF inhibitors as a promising direction for improving antitumor treatments.