For example, age-related hypermethylation within the promoter regions of tumor suppressor and metabolic genes may partially explain the increased susceptibility of the elderly to tumors and various metabolic disorders.46 Conversely, DNMT inhibitor decitabine can reverse hypermethylation in tumor suppressors, enhancing their expression and inducing a senescence-like phenotype in tumor cell lines.47 Other mechanisms, such as histone modifications and chromatin remodeling, are also strongly linked to aging. The gene discussed is DNMT1; the disease is neoplasm.