Meclofenamic acid (MA), an FDA-approved nonsteroidal anti-inflammatory drug, binds selectively to similar sites on FTO.681 MA and its prodrug, MA2, have shown promising results in reversing tumor progression and enhancing the efficacy of chemotherapeutic drugs, significantly prolonging survival.681,682 Inspired by MA, various compounds have been developed, such as the fluorescein derivative FL1, which retains the benzyl carboxylic acid structure critical for interaction with FTO. Here, FTO is linked to neoplasm.