KDM6B and chordoma: For instance, KDOBA67, a hydroxyl derivative of GSK-J4, demonstrates favorable cell permeability in chordoma cell lines and inhibits the progression of chordoma.616 Employing a virtual fragment screening approach, Giordano et al.617 identified a series of benzoxazole scaffold compounds that bind to the KDM6B subfamily with high affinity, showing therapeutic promise in melanoma cell lines.