O4I3 generates and sustains patient-specific induced pluripotent stem cells in vitro.606 Additionally, TK-129, a pyrazole-based KDM5B inhibitor, is applied in treating cardiovascular diseases.607 High-throughput screening technology has facilitated the identification of PBIT, another novel KDM5B inhibitor. The gene discussed is KDM5B; the disease is cardiovascular disorder.