METTL3 and neoplasm: While research has predominantly focused on METTL3 inhibitors, there is also interest in agonists, given their potential benefits in DNA damage repair, tumor therapies, and regenerative medicine.669–672 In 2019, Selberg et al.673 predicted interactions between four small-molecule ligands with METTL3 involving piperidine and piperazine rings, similar to SAM’s binding.