DNMT1 and Huntington disease: Studies have shown the positive effects of using DNMT inhibitors, HDAC inhibitors, and extracellular vesicles loaded with miRNAs in preventing mutant huntingtin-induced neurotoxicity, emphasizing the potential roles of epigenetic dysregulations in HD.129–131 Recently, the impact of aberrant m6A RNA methylation on the progression of HD has been increasingly recognized.