BPTF and melanoma: AU1, the first small molecule selective for BPTF, has shown effectiveness in mouse models of gastric cancer and neuroblastoma.516,523,524 Bromosporine has exhibited significant antitumor effects in breast cancer and melanoma, suggesting promising therapeutic strategies for solid tumors.525,526 The novel selective inhibitor C620-0696 has shown cytotoxic effects in non-small-cell lung cancer cells overexpressing BPTF.527 The continued exploration of these inhibitors in oncology is highly anticipated.