Utilizing computational tools to predict potential allosteric sites has led to the identification of some allosteric SIRT6 inhibitors, including JYQ-42,447 compound 11e,448 and a pyrrole-pyridinimidazole derivative.449,450 Given that histone deacetylation catalyzed by SIRT6 promotes both tumor and non-tumor diseases, designing and in-depth study of these allosteric SIRT6 inhibitors represent a promising research field for human disease treatment.451,452. The gene discussed is SIRT6; the disease is neoplasm.