TCP, an irreversible inhibitor, is being used in clinical practice among patients with AML and MDS, showing promising effects either alone or in combination with all-trans-retinoic acid in phase I/II clinical trials, with overall response rates exceeding 20%.621,622 Building on TCP’s structure, novel inhibitors like ORY-1001, ORY-2001, GSK-2879552, INCB059872, and IMG-7289 have been developed, which also bind irreversibly to LSD1.623 These advancements have broadened the spectrum of treatable diseases with LSD1 inhibitors. This evidence concerns the gene KDM1A and myelodysplastic syndrome.