METTL3 and acute myeloid leukemia: They show an inhibitory effect in the presence of METTL3/14 complex, instead of separate METTL3 and METTL14 subunits.663 The third compound, eltrombopag (previously mentioned as a TET agonist), is recently reported to bind with the METTL3 subunit at an allosteric site and has shown potential in treating AML.663,664