A number of natural and synthetic compounds, including 17‐allylamino‐17‐demethoxygeldanamycin, parthenolide, wogonin, and luteolin have been shown to inhibit TNF‐α activated NF‐kB pathways, resulting in TNF‐α induced cytotoxicity of tumour cells [71, 72, 73, 74]. Here, NFKB1 is linked to neoplasm.